Launching Of Immunization with the Vaccine Mycobacterium Indicus Pranii for Eradication of Leprosy in India

نویسندگان

  • G. P. Talwar
  • Jagdish C. Gupta
چکیده

Vaccines are developed to mobilize the immune system of the recipient to react against an invading micro-organism and thus prevent infection to occur in the body. Besides immuno-prophylaxis, several vaccines have also revealed their precious immuno-therapeutic properties. Yet another highly important function of vaccines is their utilization for “Eradication” of a disease. Eradication of small pox could not have been achieved without a vaccine. The same is being achieved for elimination of Poliomyelitis in several countries with the massive immunization of the children with the available vaccines, oral and/or injectable.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Development of a potent invigorator of immune responses endowed with both preventive and therapeutic properties

This article reviews briefly the making of an immunoprophylactic-cum-immunotherapeutic vaccine against leprosy. The vaccine is based on cultivable, heat-killed atypical mycobacteria, whose gene sequence is now known. It has been named Mycobacterium indicus pranii. It has received the approval of the Drug Controller General of India and the US Food and Drug Administration. Besides leprosy, M. in...

متن کامل

Making of Vaccines against Human Chorionic Gonadotrophin for Control of Fertility of Women without Impairment of Ovulation and Menstrual Regularity

Reviewed briefly is the development of a unique vaccine against hCG, which prevents unwanted pregnancy without blocking ovulation and disturbing menstrual regularity. A recombinant version of this vaccine, amenable to largescale production by industry, in both DNA and protein form has been made. Priming with DNA followed by protein improves further its immunogenicity. Mycobacterium indicus pran...

متن کامل

Mycobacterium indicus pranii Supernatant Induces Apoptotic Cell Death in Mouse Peritoneal Macrophages In Vitro

Mycobacterium indicus pranii (MIP), also known as Mw, is a saprophytic, non-pathogenic strain of Mycobacterium and is commercially available as a heat-killed vaccine for leprosy and recently tuberculosis (TB) as part of MDT. In this study we provide evidence that cell-free supernatant collected from original MIP suspension induces rapid and enhanced apoptosis in mouse peritoneal macrophages in ...

متن کامل

Expression of CXCL10 (IP-10) and CXCL11 (I-TAC) chemokines during Mycobacterium tuberculosis infection and immunoprophylaxis with Mycobacterium indicus pranii (Mw) in guinea pig.

Mycobacterium indicus pranii (earlier known as Mycobacterium w) has been used as an immunmodulatory agent in leprosy and tuberculosis by mediating the release of various cytokines and chemokines. CXCL10 (IP-10) and CXCL11 (I-TAC) chemokines are involved in T-cell migration and stimulation of natural killer cells in Mycobacterium tuberculosis infection. In this study, the effect of heat killed M...

متن کامل

Comparative Analyses of Nonpathogenic, Opportunistic, and Totally Pathogenic Mycobacteria Reveal Genomic and Biochemical Variabilities and Highlight the Survival Attributes of Mycobacterium tuberculosis

UNLABELLED Mycobacterial evolution involves various processes, such as genome reduction, gene cooption, and critical gene acquisition. Our comparative genome size analysis of 44 mycobacterial genomes revealed that the nonpathogenic (NP) genomes were bigger than those of opportunistic (OP) or totally pathogenic (TP) mycobacteria, with the TP genomes being smaller yet variable in size--their geno...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2017